ACINETOBACTER NEJM PDF

Turan Bloodstream Infection Infection of the bloodstream remains a life-threatening occurrence and is most commonly associated with the presence of a central vascular catheter but may also be associated with a gram-negative infection in other areas of the body, such as the lung, genitourinary tract, or abdomen. Jejm Center Support Center. There is avinetobacter much debate about the role of combination therapy versus monotherapy for gram-negative infections. Therefore, we recommend institution-tailored combination therapy for the empirical treatment of serious hospital-acquired gram-negative infections, followed by de-escalation to monotherapy once susceptibilities have been determined.

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This article has been cited by other articles in PMC. Abstract A prospective study of Acinetobacter isolates from a neonatal intensive care unit was performed for 24 months. Fifty-six isolates were obtained from 21 patients, and another eight were obtained from environmental specimens.

Infection due to Acinetobacter organisms was established for 16 patients, 6 with septicemia, 9 with pneumonia, and 1 with a wound infection. Further investigations were performed with 38 representative isolates. Twenty-nine isolates were identified as unnamed DNA-DNA hybridization group genomospecies 3, three were identified as genomospecies 2 Acinetobacter baumannii , one was identified as genomospecies 5 Acinetobacter junii , three were identified as genomospecies 14, and two were unclassified.

Eight distinguishable protein profiles, coded I through VIII, were found by cell envelope protein electrophoresis. Profile V, a common profile, was observed for 17 isolates that had been recovered from 11 patients and 1 dust specimen.

These isolates, all of which belonged to genomospecies 3, had similar antibiograms and biotypes. This study has revealed that genomospecies 3 can be associated with infection and be spread in hospitals. Selected References These references are in PubMed. This may not be the complete list of references from this article. Fingerprinting Acinetobacter strains from clinical sources by numerical analysis of electrophoretic protein patterns.

J Med Microbiol. Epidemic bacteremia due to Acinetobacter baumannii in five intensive care units. Am J Epidemiol. Epidemiology of nosocomial infections due to Acinetobacter calcoaceticus.

J Hosp Infect. Identification and biotyping of clinical isolates of Acinetobacter. Ann Inst Pasteur Microbiol. Delineation of new proteolytic genomic species in the genus Acinetobacter. Res Microbiol. Species, biotype, and bacteriophage type determinations compared with cell envelope protein profiles for typing Acinetobacter strains.

J Clin Microbiol. Control of an epidemic spread of a multi-resistant strain of Acinetobacter calcoaceticus in a hospital. Intensive Care Med. Cell envelope protein profiles of Acinetobacter calcoaceticus strains isolated in hospitals. Endemic acinetobacter in intensive care units: epidemiology and clinical impact. J Clin Pathol. Comparison of clinical Acinetobacter strains using a carbon source growth assay. Epidemiol Infect. Ribotyping of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex.

Reliability of phenotypic tests for identification of Acinetobacter species. Infections with Acinetobacter calcoaceticus Herellea vaginicola : clinical and laboratory studies.

Medicine Baltimore Mar;56 2 — Moraxella, Acinetobacter, and the Mimeae. Bacteriol Rev. Acinetobacter meningitis: acquired infection in a neonatal intensive care unit. Arch Dis Child. An outbreak of acinetobacter septicaemia in a neonatal intensive care unit.

Acinetobacter calcoaceticus biovar anitratus septicaemia in a neonatal intensive care unit: epidemiology and control. An outbreak of Acinetobacter calcoaceticus infection in a neonatal care unit. J Infect Dis. Nosocomial acinetobacter meningitis secondary to invasive procedures: report of 25 cases and review. Clin Infect Dis. Investigation of an outbreak of infection with Acinetobacter calcoaceticus in a special care baby unit.

Acinetobacter baumannii serotyping for delineation of outbreaks of nosocomial cross-infection. Laboratory investigation of hospital outbreak caused by two different multiresistant Acinetobacter calcoaceticus subsp. Identification of Acinetobacter species.

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ACINETOBACTER NEJM PDF

Abstract Background Acinetobacter baumannii can cause serious healthcare-associated infections HAIs and the incidence is increasing, with many strains now resistant to multiple antibiotic classes. The aims of this study were to examine factors associated with HAIs caused by antimicrobial-resistant as compared with antimicrobial-susceptible strains of A. Electronic data from two U. Multiple logistic regression was used to explore risk factors for infection with A. The Cochran-Armitage trend test was used to explore resistance trends over time.

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